I have been settling into a routine for my photography and using the Pentax K-1 II camera with the 28-105mm lens for my personal photography and the Nikon Z5 with the 24-200mm lens primarily for Homewood photography. They are both full frame cameras and I can use either one to back the other up. I prefer the Pentax for walking about when I occasionally see wildlife or need the better LCD for down low detail photography even though it weighs 6.5 ounces more. I also prefer the Pentax for cropping and processing images. For Homewood photography I generally use jpegs with minor processing.
The primary usability differences other than size and weight are:
The Nikon is silent. The Pentax isn’t.
The Pentax is more rugged and weather resistant.
The Pentax has a 36MP sensor, the Nikon has a 24mm sensor.
The Pentax has a rugged multi-tilt LCD, the Nikon’s is more limited in flexibility.
I prefer the hand grip, controls, and ergonomics of the Pentax.